Cunningham Panel™ effectively identifies acute illness in Sydenham chorea and PANDAS patients

This newly published article by Dr. Madeleine Cunningham and colleagues examines autoantibody biomarkers for basal ganglia encephalitis (BGE) in a set of patients with Sydenham Chorea (SC) and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS). Evidence strongly suggests that both PANDAS and SC are manifestations of basal ganglia encephalitis provoked by cross-reactive anti-neuronal antibodies.

See article below as well as the video of Dr. Cunningham’s additional explanations.

Study demonstrates clinical value of the Cunningham Panel™ and accuracy in patients with symptoms of an autoimmune encephalopathy

Cunningham Panel biomarkers and their significance

This newly published study examined whether changes in patient pre- and post-treatment symptoms correlated with changes in anti-neuronal autoantibody titers and the neuronal cell stimulation assay in the Cunningham Panel in patients with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS), and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS).

COVID-19 viral infection may increase risk of neuropsychiatric sequelae

Acute neuropsychiatric symptoms in COVID-19 cases are emerging. This newly published article describes the potential impact of COVID-19 viral infections and the risk of developing neuropsychiatric complications.

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