Case Report: PANDAS and persistent Lyme Disease With Neuropsychiatric Symptoms: Treatment, Resolution and Recovery

by Amy Cross, Denis Boubouolis, Craig Shimasaki and Charles Ray Jones

The subject of this case report had a concomitant diagnosis of Lyme borreliosis and PANDAS, both of which are consistent with the neuropsychiatric symptoms she experienced. As evidenced by her recovery and resolution of symptoms, treating both the Lyme infection and streptococcal infection, as well as treating the underlying autoimmune etiology of her neuropsychiatric symptoms resulted in a successful outcome. … The post-treatment resolution of these autoantibodies provided pathophysiological support for addressing both the infection(s) and the underlying immune system dysfunction which resulted in a positive medical outcome for this patient.

Cunningham Panel™ effectively identifies acute illness in Sydenham chorea and PANDAS patients

This newly published article by Dr. Madeleine Cunningham and colleagues examines autoantibody biomarkers for basal ganglia encephalitis (BGE) in a set of patients with Sydenham Chorea (SC) and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS). Evidence strongly suggests that both PANDAS and SC are manifestations of basal ganglia encephalitis provoked by cross-reactive anti-neuronal antibodies.

See article below as well as the video of Dr. Cunningham’s additional explanations.

Study demonstrates clinical value of the Cunningham Panel™ and accuracy in patients with symptoms of an autoimmune encephalopathy

Cunningham Panel biomarkers and their significance

This newly published study examined whether changes in patient pre- and post-treatment symptoms correlated with changes in anti-neuronal autoantibody titers and the neuronal cell stimulation assay in the Cunningham Panel in patients with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS), and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS).

COVID-19 viral infection may increase risk of neuropsychiatric sequelae

Acute neuropsychiatric symptoms in COVID-19 cases are emerging. This newly published article describes the potential impact of COVID-19 viral infections and the risk of developing neuropsychiatric complications.

Autoimmune-induced seizures in adults with no history

Seizures in adults with no seizure history can be caused by a number of factors ranging from high blood pressure, drug abuse and toxic exposures to brain injury, brain infection (encephalitis) and heart disease. Mounting evidence also indicates that an immune dysfunction or abnormal autoimmune activity can elicit a sudden onset of seizures in adults with no history of the illness.

It’s well-established that people with certain autoimmune disorders, such as lupus, type 1 diabetes, celiac disease, multiple sclerosis, rheumatoid arthritis, and psoriasis, are at greater risk of developing epileptic seizures. Studies put the risk as high as 4-fold in adults and 5-fold in children. According to researchers, “Immune dysfunction may be partly responsible for this association.”