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MITOCHONDRIAL TESTING
WITH AONM/MMD

 

References

Click here for Prof. Brigitte König’s publication list

Chacko BK, Kramer PA, Ravi S, Benavides GA, Mitchell T, Dranka BP, Ferrick D, Singal AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, Darley-Usmar VM. The Bioenergetic Health Index: a new concept in mitochondrial translational research. Clin Sci (Lond). 2014 Sep;127(6):367–73; https://pubmed.ncbi.nlm.nih.gov/24895057/

Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S, Ferrick DA. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol. 2007 Jan;292(1):C125-36. 

Kramer PA, Chacko BK, George DJ, Zhi D, Wei CC, Dell’Italia LJ, Melby SJ, George JF, Darley-Usmar VM. Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients. Biosci Rep. 2015 Jul 1;35(4):e00237.

Chacko BK, Zhi D, Darley-Usmar VM, Mitchell T. The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytes. Redox Biol. 2016 Aug;8:43-50. 

Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. Biochem J. 2011 Apr 15;435(2):297-312. 

Mookerjee SA, Gerencser AA, Nicholls DG, Brand MD. Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements. J Biol Chem. 2017 Apr 28;292(17):7189-7207. 

Kramer PA, Ravi S, Chacko B, Johnson MS, Darley-Usmar VM. A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: implications for their use as bioenergetic biomarkers. Redox Biol. 2014 Jan 10;2:206-10.

Gerencser AA, Neilson A, Choi SW, Edman U, Yadava N, Oh RJ, Ferrick DA, Nicholls DG, Brand MD. Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem. 2009 Aug 15;81(16):6868-78. 

Koklesova, Lenka & Mazurakova, Alena & Samec, Marek & Kudela, Erik & Biringer, Kamil & Kubatka, Peter & Golubnitschaja, Olga. (2022). Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine. EPMA Journal.

Hill BG, Benavides GA, Lancaster JR Jr, Ballinger S, Dell’Italia L, Jianhua Z, Darley-Usmar VM. Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem. 2012 Dec;393(12):1485-1512.

Bakare AB, Dean J, Chen Q, Thorat V, Huang Y, LaFramboise T, Lesnefsky EJ, Iyer S. Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity. Int J Mol Sci. 2021 Sep 26;22(19):10344. 

Cumming BM, Addicott KW, Adamson JH, Steyn AJ. Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages. Elife. 2018 Nov 16;7:e39169

Chacko, B. K. (24. Dec. 2015). The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytes. Redox Biology, S. 43-50.

Chacko, B. K. (25. March 2013). Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Laboratory Investigation, S. 690-700.

Rousset, S. e. (Feb. 2004). The Biology of Mitochondrial Uncoupling Proteins. DIABETES, S. 130-135.

Nguyen, T. e. (15. May 2009). The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress. Journal of biological chemistry, S. 13291-13295.

Austin, S. e. (2012). PGC1a and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders. Journal of Cell Science, S. 4963-4971.

St-Pierre, J. e. (20. Oct 2006). Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators. Cell Press, S. 397-408.

Guo, W. e. (1. Jul. 2010). DNA Extraction Procedures Meaningfully Influence qPCR-Based mtDNA Copy Number Determination. Mitochondrion,
S. 261-265.

Bordo, D. e. (3. Jun. 2002). The rhodanese/Cdc25 phosphatase superfamily. EMBO reports, S. 741-746.

Gliubich, F. e. (30. Aug. 1996). Active Site Structural Features for Chemically Modified Forms of Rhodanese. The Journal of biological chemistry,
S. 21054–21061.

Hildebrandt, T. e. (29. Apr. 2008). Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. The FEBS journal, S. 3352-3361.

Proton Leak

Divakaruni AS, Brand MD. The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda). 2011 Jun;26(3):192-205.

Brand MD, Chien LF, Ainscow EK, Rolfe DF, Porter RK. The causes and functions of mitochondrial proton leak. Biochim Biophys Acta. 1994 Aug 30;1187(2):132-9. 

Jastroch M, Divakaruni AS, Mookerjee S, Treberg JR, Brand MD. Mitochondrial proton and electron leaks. Essays Biochem. 2010;47:53-67.

https://www.physoc.org/magazine-articles/the-leaky-mitochondrion/

Krauss S, Zhang CY, Lowell BB. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):118-22. 

 

Further references available upon request