Scientific articles and studies

Publications on maintrac

Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology

Chick chorioallantoic membrane (CAM) assays as a model of xenografts derived from circulating cancer stem cells from breast cancer patients.

Monika Pizon, Dorothea Schott, Ulrich A. Pachmann, Katharina Pachmann, Rainer Schobert

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Successful mutational profiling of single circulating epithelial tumor cells (CETCs) from patients with solid cancers for guiding therapy

Maintrac newsletter: Background: Circulating epithelial tumor cells (CETCs) are an important link between primary tumors and metastases and provide a readily accessible source of tumor material from patients with solid cancer.Read more

The latest publications 2020

Author: Payer P, Röder M, Camara O, Pachmann K. Title: High depletion of breast cancer cells from the peripheral blood with the method of non-specific separation. ecancer 2020, 14:1003

Therapy Relevant Characteristics of Circulating Tumor Cells

Maintrac newsletter
For a patient, cancer is an intrusive diagnosis entailing many changes and consequences. Medicine and research face difficult challenges with this highly complex disease. The heterogeneity and rapid transformability of tumours is particularly challenging for diagnostics and therapy. Read more

Therapy Relevant Characteristics of Circulating Tumor Cells

Maintrac newsletter: Growth factor receptors
The effect of growth factors is mediated via binding to receptors on the surface of target cells. The receptor proteins extend through the cell membrane (transmembrane receptors). When a specific ligand binds to the extracellular domain, the receptor is activated; consequently, various signal transduction pathways are influenced, which have a direct effect either on cell metabolism or control of gene transcription. The goal of specific drugs that target these growth factor receptors is reduced growth or death of the cancer cells. However, the use of some of these drugs is possible only once the target structures on the cancer cells have been detected.Read more.

The latest publications 2019

Authors: Agrawal S, Wozniak M, Luc M, Makuch S, Pielka E, Agrawal AK, Wietrzyk J, Banach J, Gamian A, Pizon M, Ziolkowski P. Title: Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulation PIK3CA and GRB2. Scientific reports 2019, 9: 16647

The latest publications 2019

Authors: Petra Payer, Michael Röder, Oumar Camara and Katharina Pachmann
Title: High depletion of breast cancer cells from the peripheral blood with the method of non-specific separation.
ecancer medicalscience https://ecancer.org/en/journal/article/1003-high-depletion-of-breast-cancer-cells-from-the-peripheral-blood-with-the-method-of-non-specific-separation

The latest publications 2020

Author: Pachmann, K. Title: Brustkrebstherapie in Zeiten der Covid-19-Pandemie. Gyne 2020, 3:32-33

The latest publications 2018

Author: Pizon M, Lux D, Pachmann U, Pachmann K, Schott D. Title: Influence of endocrine therapy on the ratio of androgen receptor (AR) to estrogen receptor (ER) positive circulating epithelial tumor cells (CETCs) in breast cancer. J Transl Med 2018, 16(1):356

The latest publications 2018

Author: Pachmann K, Henneking, S. Title: Zirkulierende epitheliale Tumorzellen und Tumorstammzellen – Über ihren derzeitigen und zukünftigen Gebrauch bei der Überwachung des Krankheitsverlaufs von Krebspatienten. Die Naturheilkunde / Forum Komplementäre Onkologie, 2018, 5

The latest publications 2019

Author: Pachmann K, Pachmann U. Title: Brustkrebs und endokrine Therapie: zirkulierende Tumorzellen als wichtiges Entscheidungskriterium. Gyne 2019, 5:12-14

The latest publications 2018

Authors: Pachmann K, Willecke-Hochmuth R, Schneider K, Kaatz M. Title: Circulating epithelial tumor cells as a prognostic tool for malignant melanoma. Melanoma Res, 2018, 28:37-43

The latest publications 2018

Authors: Pizon M, Schott D, Pachmann U, Pachmann K.

Title: Tumorspheres cultured from peripheral blood as a biomarker for presence of metastatic disease in patients with breast cancer.

Personalized Oncology 2018, 2:65-73

The latest publications 2018

Authors: Pachmann K, Schuster S.

Title: The Value of Monitoring the Behavior of Circulating Tumor Cells at the End of Endocrine Therapy in Breast Cancer Patients.

Cancers 2018, 10,407; Doi:10.3390/cancers10110407

The latest publications 2017

Authors
Schott D, Pizon M, Schuster S, Pachmann K.   von
PD-L1/2 auf zirkulierenden Tumorellen in der Immuntherapie des Mammakarzinoms.
Onkologie heute, 2017, 6:40-42

The latest publications 2017

Schott D, Pizon M, Pachmann U, Pachmann K.
Sensitive detection of PD-L1 expression on circulatinge epithelial tumor cells (CETC) could be a potential biomarker to select patients for treatment with PD-1/PD-L1 inhibitors in early and metastatic solid tumors.
Oncotarget 2017, DOI:doi.org/10.18632/oncotarget.20346

The latest publications 2017

Pizon M, Schott D, Pachmann U, Pachmann K.
Determination of PD-L1 positive CETCs as a biomarker for PD-1/PD-L1 treatment monitoring.
Oncol Res Treat 2017, 40(suppl 3): 89 #P310

The latest publications 2017

authors:
Schott D, Pizon M, Schuster S, Pachmann K.
title:
Häufigkeit und Relevanz von PD-L1/2 auf zirkulierenden Tumorzellen in der Immuntherapie bei Brustkrebspatientinnen.
site of publication:
Gyne 2017, 2:26-28

The latest publications 2016

authors:
Schott D, Pizon M, Pachmann U, Pachmann K.
title:
Comparison of phenotype and gene expression analysis of circulating epithelial tumor cells (CETCs) and tumorspheres in colorectal cancer patients.
site of publication:
Oncol Res Treat 2016, 39(suppl 2): 272 #P897

The latest publications 2016

authors:
Pizon M, Schott D, Pachmann U, Pachmann K.
title:
The number of tumorspheres cultured from CETCs in breast cancer patients is directly related to stage of disease and administration of chemotherapy.
site of publication:
Ann Oncol 2016, 27(suppl 6): p534, #1545P

The latest publications 2016

authors:
Regina Willecke-Hochmuth, Katharina Pachmann, Joachim Drevs
title:
Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography‑computed tomography imaging
site of publication:
ONCOLOGY LETTERS 12: 1711-1716, 2016

The latest publications 2016

authors:
Pizon M, Schott D, Pachmann K, Pachmann U.
title:
The number of tumorspheres cultured from peripheral blood is a predictor for presence of metastasis in patients with breast cancer.
site of publication:
Oncotarget, Advance Publications 2016, doi:

The latest publications 2016

authors:
Schuster S, Pachmann K.
title:
Zirkulierende epitheliale Tumorzellen: Echtzeitkontrolle in der adjuvanten Krebstherapie, der Erhaltungstherapie und Langzeitüberwachung.
site of publication:
DZKF 2016, 1:46-50

The latest publications 2016

authors:
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
Frequent expression of PDL-1 on circulating epithelial tumor cells (CETCs) could be a new therapeutic target in breast cancer patients.
site of publication:
Oncol Res Treat 2016, 39(suppl1):D0303

The latest publications 2016

authors:
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
PDL-1 is more frequently expressed on circulating epithelial tumor cells (CETCs) in metastatic breast cancer patients and could be a crucial factor in the inhibition of immune response to CETCs during metastatsis formation.
site of publication:
Molecular Cancer Therapeutics 2016, #B95

The latest publications 2016

authors:
Zimon D, Pizon M, Mayer V, Pachmann K.
title:
Stem cell markers are overexpressed in tumorsheres cultured from circulating epithelial tumor cells (CETCs) in patients with breast cancer.
site of publication:
Cancer Res 2016, 76:P3-07-59, doi: 10.1158/1538-7445.SABCS 15-P3-07-59

The latest publications 2015

authors:
Zimon D, Pizon M, Maier V, Pachmann U, Pachmann K.
title:
Tumorsphären, die aus CETCs von Patienten mit soliden Tumoren kultiviert wurden, zeigen eine überexpression von Stammzellmarkern.
site of publication:
Oncol Res Treatment 2015, 38 (suppl 5): 1-288 (P-502)

The latest publications 2015

authors:
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
Die Anzahl der aus CECTs kultivierten Tumorsphären hängt von dem Stadium der Krankheit und dem Einsatz einer Chemotherapie ab.
site of publication:
Oncol Res Treatment 2015, 38 (suppl 5): 1-288 (V-631)

The latest publications 2015

authors:
Pizon M, Zimon D, Maier V, Pachmann U, Pachmann K.
title:
PDL-1 is highly expressed on circulating epithelial tumor cells (CETCs) and could ba a crucial factor in the inhibition of immune response to CETCs during metastasis formation.
site of publication:
EJC 2015, 51 (suppl 3): p 18-19

The latest publications 2015

authors:
Zimon D, Pizon M, Pachmann U, Pachmann K.
title:
Characterisation of tumorspheres cultured from circulating epithelial tumor cells (CETCs) in pancreatic cancer patients.
site of publication:
EJC 2015, 51 (suppl 3): p6

The latest publications 2015

authors:
Zimon D, Pizon M, Stein EL, Pachman UA, Pachmann K.
title:
Vemurafenib to eliminate BRAF-mutated circulating epithelial tumor cells (CETCs) from blood of patients with malignant melanoma.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e11031)

The latest publications 2015

authors:
Pizon M, Zimon D, Pachmann UA, Pachmann K.
title:
Tumorspheres cultured from circulating epithelial tumor cells (CETCs) in pancreatic cancer patients having cancer stem cells properties and resistance to standard chemotherapeutics.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e22031)

The latest publications 2015

authors:
Pizon M, Zimon D, Pachmann UA, Pachmann K.
title:
The number of tumorspheres cultured from CETCs in breast cancer patients in relation to stage of the disease and administration of chemotherapy.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e22032)

The latest publications 2015

authors:
Pachmann K, Schuster, S.
title:
Brustkrebs-Ãœberwachung nach Ende der Hormontherapie: Bieten zirkulierende epitheliale Tumorzellen eine Entscheidungshilfe?
site of publication:
Gyne 2015, 05:28-32

The latest publications 2015

authors:
Pachmann K, Schuster S.
title:
Brustkrebsüberwachung: Bieten zirkulierende epitheliale Tumorzellen eine Entscheidungshilfe?
site of publication:
DZKF 2015, 3:15-19

The latest publications 2015

authors:
Guntinas-Lichius O, Pachmann K.
title:
Zirkulierende Tumorzellen bei Kopf-Hals-Tumoren.
site of publication:
DOI 10.1055/s-0035-1548921, Laryngo-Rhino-Otol 2015, 94:367-73

The latest publications 2015

authors:
Pachmann K.
title:
Wie beeinflußt die Therapie solider epithelialer Tumore die im Blut zirkulierenden Tumorzellen.
site of publication:
DZO 2015, 47:82-87

The latest publications 2015

authors:
Pachmann K.
title:
Current and potential use of MAINTRAC method for cancer diagnosis and Prediction of metastasis.
site of publication:
Expert Rev Mol Diagn

The latest publications 2015

authors:
Inhestern J, Oertel K, Stemmann V,Schmalenberg H, Dietz A, Rotter N, Veit J, Goerner M, Sudhoffs H, Junghans C, Wittekindt C, Pachmann K, Guntinas-Lichius O.
title:
Prognostic Role of Circulating Tumor Cells during Induction Chemotherapy Followed by Curative Surgery Combined with Postoperative Radiotherapy in Patients with Locally Advanced Oral and Oropharyngeal Squamous Cell Cancer.
site of publication:
PLoS One

The latest publications 2014

authors:
Mahal K, Schill E, Breyer S, Pachmann U, Pachmann K, Schobert R, Biersack B.
title:
Acitivity of a Doxorubicin Menthol Conjugate against Circulating Epithelial Tumor Cells of Cancer Patients.
site of publication:
J Pharm Sci Pharmacol 2014, 2:1-4, DOI:10.1166/jpsp.2014.1027

The latest publications 2014

authors:
Zimon D, Pizon M, Stein EL, Pachmann U, Pachmann K.
title:
Differential chemosensitivity between CETCs and tumour spherodis in cancer patients with solid tumors.
site of publication:
Europ J Cancer 2014, 50(suppl 6):62, #190

The latest publications 2014

authors:
Winkens T, Pachmann K, Fressmeyer M.
title:
The influence of radioiodine therapy on the number of circulating epitzelial cells (CEC) in patients with differentiated thyroid carcioma – a pilot study.
site of publication:
Exp Clin Endocrinol Diabetes 2014, 122: 246-253

The latest publications 2014

authors:
Pachmann K, Zimon D, Pizon M, Pachmann U.
title:
Tumor spheres growing from peripherally circulating tumor cells exhibit stem cell features.
site of publication:
Cancer Res December 15, 2013 73:PD6-1; doi:10.1158/0008-5472.SABCS13-PD6-1

The latest publications 2014

authors:
Pachmann K.
title:
Tumorspheres cutured from circulating epithelial tumor cells (CETCs) as diagnostic marker in patients with solid cancers.
site of publication:
J Clin Oncol 2014, 32:705, #11043

The latest publications 2014

authors:
Pachmann K.
title:
Comparison of chemosensitivity testing of CETCs and spheroids in cancer patients with solid tumors.
site of publication:
J Clin Oncol 2014, 32:166, #2598

The latest publications 2014

authors:
Pachmann K, Pizon M, Zimon D, Stein EL.
title:
Somatic mutations of the EGFR, KRAS and BRAF genes: Heterogeneity in circulating epithelial tumor cells (CETC) as determined using the Cobas Z480 analyzer.
site of publication:
Europ J Cancer 2013, 49(suppl.4):34(#MC13-0080)

The latest publications 2014

authors:
Zimon D, Pizon M, Pachmann U, Pachmann, Pachmann K.
title:
Determining the role of IGF-IR and VEGFR-2 in the development of resistance to trastuzumab in breast cancer.
site of publication:
Oncol Res Treat 2014, 37 (suppl 5):262(#P798)

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