Scientific articles and studies
Publications on maintrac
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Chick chorioallantoic membrane (CAM) assays as a model of xenografts derived from circulating cancer stem cells from breast cancer patients.
Monika Pizon, Dorothea Schott, Ulrich A. Pachmann, Katharina Pachmann, Rainer Schobert
Successful mutational profiling of single circulating epithelial tumor cells (CETCs) from patients with solid cancers for guiding therapy
Maintrac newsletter: Background: Circulating epithelial tumor cells (CETCs) are an important link between primary tumors and metastases and provide a readily accessible source of tumor material from patients with solid cancer.Read more
The latest publications 2020
Author: Payer P, Röder M, Camara O, Pachmann K. Title: High depletion of breast cancer cells from the peripheral blood with the method of non-specific separation. ecancer 2020, 14:1003
Therapy Relevant Characteristics of Circulating Tumor Cells
Maintrac newsletter
For a patient, cancer is an intrusive diagnosis entailing many changes and consequences. Medicine and research face difficult challenges with this highly complex disease. The heterogeneity and rapid transformability of tumours is particularly challenging for diagnostics and therapy. Read more
For a patient, cancer is an intrusive diagnosis entailing many changes and consequences. Medicine and research face difficult challenges with this highly complex disease. The heterogeneity and rapid transformability of tumours is particularly challenging for diagnostics and therapy. Read more
Therapy Relevant Characteristics of Circulating Tumor Cells
Maintrac newsletter: Growth factor receptors
The effect of growth factors is mediated via binding to receptors on the surface of target cells. The receptor proteins extend through the cell membrane (transmembrane receptors). When a specific ligand binds to the extracellular domain, the receptor is activated; consequently, various signal transduction pathways are influenced, which have a direct effect either on cell metabolism or control of gene transcription. The goal of specific drugs that target these growth factor receptors is reduced growth or death of the cancer cells. However, the use of some of these drugs is possible only once the target structures on the cancer cells have been detected.Read more.
The effect of growth factors is mediated via binding to receptors on the surface of target cells. The receptor proteins extend through the cell membrane (transmembrane receptors). When a specific ligand binds to the extracellular domain, the receptor is activated; consequently, various signal transduction pathways are influenced, which have a direct effect either on cell metabolism or control of gene transcription. The goal of specific drugs that target these growth factor receptors is reduced growth or death of the cancer cells. However, the use of some of these drugs is possible only once the target structures on the cancer cells have been detected.Read more.
The latest publications 2019
Authors: Agrawal S, Wozniak M, Luc M, Makuch S, Pielka E, Agrawal AK, Wietrzyk J, Banach J, Gamian A, Pizon M, Ziolkowski P. Title: Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulation PIK3CA and GRB2. Scientific reports 2019, 9: 16647
The latest publications 2019
Authors: Petra Payer, Michael Röder, Oumar Camara and Katharina Pachmann
Title: High depletion of breast cancer cells from the peripheral blood with the method of non-specific separation.
ecancer medicalscience https://ecancer.org/en/journal/article/1003-high-depletion-of-breast-cancer-cells-from-the-peripheral-blood-with-the-method-of-non-specific-separation
Title: High depletion of breast cancer cells from the peripheral blood with the method of non-specific separation.
ecancer medicalscience https://ecancer.org/en/journal/article/1003-high-depletion-of-breast-cancer-cells-from-the-peripheral-blood-with-the-method-of-non-specific-separation
The latest publications 2020
Author: Pachmann, K. Title: Brustkrebstherapie in Zeiten der Covid-19-Pandemie. Gyne 2020, 3:32-33
The latest publications 2018
Author: Pizon M, Lux D, Pachmann U, Pachmann K, Schott D. Title: Influence of endocrine therapy on the ratio of androgen receptor (AR) to estrogen receptor (ER) positive circulating epithelial tumor cells (CETCs) in breast cancer. J Transl Med 2018, 16(1):356
The latest publications 2018
Author: Pachmann K, Henneking, S. Title: Zirkulierende epitheliale Tumorzellen und Tumorstammzellen – Über ihren derzeitigen und zukünftigen Gebrauch bei der Überwachung des Krankheitsverlaufs von Krebspatienten. Die Naturheilkunde / Forum Komplementäre Onkologie, 2018, 5
The latest publications 2019
Author: Pachmann K, Pachmann U. Title: Brustkrebs und endokrine Therapie: zirkulierende Tumorzellen als wichtiges Entscheidungskriterium. Gyne 2019, 5:12-14
The latest publications 2018
Authors: Pachmann K, Willecke-Hochmuth R, Schneider K, Kaatz M. Title: Circulating epithelial tumor cells as a prognostic tool for malignant melanoma. Melanoma Res, 2018, 28:37-43
The latest publications 2018
Authors: Pizon M, Schott D, Pachmann U, Pachmann K.
Title: Tumorspheres cultured from peripheral blood as a biomarker for presence of metastatic disease in patients with breast cancer.
Personalized Oncology 2018, 2:65-73
The latest publications 2018
Authors: Pachmann K, Schuster S.
Title: The Value of Monitoring the Behavior of Circulating Tumor Cells at the End of Endocrine Therapy in Breast Cancer Patients.
Cancers 2018, 10,407; Doi:10.3390/cancers10110407
The latest publications 2017
authors:
Schott D, Pizon M, Schuster S, Pachmann K.
title:
Haufigkeit und Relevanz von PD-L1/2 auf zirkulierenden Tumorzellen in der Immuntherapie bei Brustkrebspatientinnen.
site of publication:
Gyne 2017, 2:26-28
Schott D, Pizon M, Schuster S, Pachmann K.
title:
Haufigkeit und Relevanz von PD-L1/2 auf zirkulierenden Tumorzellen in der Immuntherapie bei Brustkrebspatientinnen.
site of publication:
Gyne 2017, 2:26-28
The latest publications 2016
authors:
Schott D, Pizon M, Pachmann U, Pachmann K.
title:
Comparison of phenotype and gene expression analysis of circulating epithelial tumor cells (CETCs) and tumorspheres in colorectal cancer patients.
site of publication:
Oncol Res Treat 2016, 39(suppl 2): 272 #P897
Schott D, Pizon M, Pachmann U, Pachmann K.
title:
Comparison of phenotype and gene expression analysis of circulating epithelial tumor cells (CETCs) and tumorspheres in colorectal cancer patients.
site of publication:
Oncol Res Treat 2016, 39(suppl 2): 272 #P897
The latest publications 2016
authors:
Pizon M, Schott D, Pachmann U, Pachmann K.
title:
The number of tumorspheres cultured from CETCs in breast cancer patients is directly related to stage of disease and administration of chemotherapy.
site of publication:
Ann Oncol 2016, 27(suppl 6): p534, #1545P
Pizon M, Schott D, Pachmann U, Pachmann K.
title:
The number of tumorspheres cultured from CETCs in breast cancer patients is directly related to stage of disease and administration of chemotherapy.
site of publication:
Ann Oncol 2016, 27(suppl 6): p534, #1545P
The latest publications 2016
authors:
Regina Willecke-Hochmuth, Katharina Pachmann, Joachim Drevs
title:
Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography computed tomography imaging
site of publication:
ONCOLOGY LETTERS 12: 1711-1716, 2016
Regina Willecke-Hochmuth, Katharina Pachmann, Joachim Drevs
title:
Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography computed tomography imaging
site of publication:
ONCOLOGY LETTERS 12: 1711-1716, 2016
The latest publications 2016
authors:
Pizon M, Schott D, Pachmann K, Pachmann U.
title:
The number of tumorspheres cultured from peripheral blood is a predictor for presence of metastasis in patients with breast cancer.
site of publication:
Oncotarget, Advance Publications 2016, doi:
Pizon M, Schott D, Pachmann K, Pachmann U.
title:
The number of tumorspheres cultured from peripheral blood is a predictor for presence of metastasis in patients with breast cancer.
site of publication:
Oncotarget, Advance Publications 2016, doi:
The latest publications 2016
authors:
Schuster S, Pachmann K.
title:
Zirkulierende epitheliale Tumorzellen: Echtzeitkontrolle in der adjuvanten Krebstherapie, der Erhaltungstherapie und Langzeituberwachung.
site of publication:
DZKF 2016, 1:46-50
Schuster S, Pachmann K.
title:
Zirkulierende epitheliale Tumorzellen: Echtzeitkontrolle in der adjuvanten Krebstherapie, der Erhaltungstherapie und Langzeituberwachung.
site of publication:
DZKF 2016, 1:46-50
The latest publications 2016
authors:
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
Frequent expression of PDL-1 on circulating epithelial tumor cells (CETCs) could be a new therapeutic target in breast cancer patients.
site of publication:
Oncol Res Treat 2016, 39(suppl1):D0303
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
Frequent expression of PDL-1 on circulating epithelial tumor cells (CETCs) could be a new therapeutic target in breast cancer patients.
site of publication:
Oncol Res Treat 2016, 39(suppl1):D0303
The latest publications 2016
authors:
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
PDL-1 is more frequently expressed on circulating epithelial tumor cells (CETCs) in metastatic breast cancer patients and could be a crucial factor in the inhibition of immune response to CETCs during metastatsis formation.
site of publication:
Molecular Cancer Therapeutics 2016, #B95
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
PDL-1 is more frequently expressed on circulating epithelial tumor cells (CETCs) in metastatic breast cancer patients and could be a crucial factor in the inhibition of immune response to CETCs during metastatsis formation.
site of publication:
Molecular Cancer Therapeutics 2016, #B95
The latest publications 2016
authors:
Zimon D, Pizon M, Mayer V, Pachmann K.
title:
Stem cell markers are overexpressed in tumorsheres cultured from circulating epithelial tumor cells (CETCs) in patients with breast cancer.
site of publication:
Cancer Res 2016, 76:P3-07-59, doi: 10.1158/1538-7445.SABCS 15-P3-07-59
Zimon D, Pizon M, Mayer V, Pachmann K.
title:
Stem cell markers are overexpressed in tumorsheres cultured from circulating epithelial tumor cells (CETCs) in patients with breast cancer.
site of publication:
Cancer Res 2016, 76:P3-07-59, doi: 10.1158/1538-7445.SABCS 15-P3-07-59
The latest publications 2015
authors:
Zimon D, Pizon M, Maier V, Pachmann U, Pachmann K.
title:
Tumorsphären, die aus CETCs von Patienten mit soliden Tumoren kultiviert wurden, zeigen eine überexpression von Stammzellmarkern.
site of publication:
Oncol Res Treatment 2015, 38 (suppl 5): 1-288 (P-502)
Zimon D, Pizon M, Maier V, Pachmann U, Pachmann K.
title:
Tumorsphären, die aus CETCs von Patienten mit soliden Tumoren kultiviert wurden, zeigen eine überexpression von Stammzellmarkern.
site of publication:
Oncol Res Treatment 2015, 38 (suppl 5): 1-288 (P-502)
The latest publications 2015
authors:
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
Die Anzahl der aus CECTs kultivierten Tumorsphären hängt von dem Stadium der Krankheit und dem Einsatz einer Chemotherapie ab.
site of publication:
Oncol Res Treatment 2015, 38 (suppl 5): 1-288 (V-631)
Pizon M, Zimon D, Pachmann U, Pachmann K.
title:
Die Anzahl der aus CECTs kultivierten Tumorsphären hängt von dem Stadium der Krankheit und dem Einsatz einer Chemotherapie ab.
site of publication:
Oncol Res Treatment 2015, 38 (suppl 5): 1-288 (V-631)
The latest publications 2015
authors:
Pizon M, Zimon D, Maier V, Pachmann U, Pachmann K.
title:
PDL-1 is highly expressed on circulating epithelial tumor cells (CETCs) and could ba a crucial factor in the inhibition of immune response to CETCs during metastasis formation.
site of publication:
EJC 2015, 51 (suppl 3): p 18-19
Pizon M, Zimon D, Maier V, Pachmann U, Pachmann K.
title:
PDL-1 is highly expressed on circulating epithelial tumor cells (CETCs) and could ba a crucial factor in the inhibition of immune response to CETCs during metastasis formation.
site of publication:
EJC 2015, 51 (suppl 3): p 18-19
The latest publications 2015
authors:
Zimon D, Pizon M, Pachmann U, Pachmann K.
title:
Characterisation of tumorspheres cultured from circulating epithelial tumor cells (CETCs) in pancreatic cancer patients.
site of publication:
EJC 2015, 51 (suppl 3): p6
Zimon D, Pizon M, Pachmann U, Pachmann K.
title:
Characterisation of tumorspheres cultured from circulating epithelial tumor cells (CETCs) in pancreatic cancer patients.
site of publication:
EJC 2015, 51 (suppl 3): p6
The latest publications 2015
authors:
Zimon D, Pizon M, Stein EL, Pachman UA, Pachmann K.
title:
Vemurafenib to eliminate BRAF-mutated circulating epithelial tumor cells (CETCs) from blood of patients with malignant melanoma.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e11031)
Zimon D, Pizon M, Stein EL, Pachman UA, Pachmann K.
title:
Vemurafenib to eliminate BRAF-mutated circulating epithelial tumor cells (CETCs) from blood of patients with malignant melanoma.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e11031)
The latest publications 2015
authors:
Pizon M, Zimon D, Pachmann UA, Pachmann K.
title:
Tumorspheres cultured from circulating epithelial tumor cells (CETCs) in pancreatic cancer patients having cancer stem cells properties and resistance to standard chemotherapeutics.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e22031)
Pizon M, Zimon D, Pachmann UA, Pachmann K.
title:
Tumorspheres cultured from circulating epithelial tumor cells (CETCs) in pancreatic cancer patients having cancer stem cells properties and resistance to standard chemotherapeutics.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e22031)
The latest publications 2015
authors:
Pizon M, Zimon D, Pachmann UA, Pachmann K.
title:
The number of tumorspheres cultured from CETCs in breast cancer patients in relation to stage of the disease and administration of chemotherapy.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e22032)
Pizon M, Zimon D, Pachmann UA, Pachmann K.
title:
The number of tumorspheres cultured from CETCs in breast cancer patients in relation to stage of the disease and administration of chemotherapy.
site of publication:
J Clin Oncol 2015, 33 (suppl; abstr e22032)
The latest publications 2015
authors:
Pachmann K, Schuster, S.
title:
Brustkrebs-Ãœberwachung nach Ende der Hormontherapie: Bieten zirkulierende epitheliale Tumorzellen eine Entscheidungshilfe?
site of publication:
Gyne 2015, 05:28-32
Pachmann K, Schuster, S.
title:
Brustkrebs-Ãœberwachung nach Ende der Hormontherapie: Bieten zirkulierende epitheliale Tumorzellen eine Entscheidungshilfe?
site of publication:
Gyne 2015, 05:28-32
The latest publications 2015
authors:
Pachmann K, Schuster S.
title:
Brustkrebsüberwachung: Bieten zirkulierende epitheliale Tumorzellen eine Entscheidungshilfe?
site of publication:
DZKF 2015, 3:15-19
Pachmann K, Schuster S.
title:
Brustkrebsüberwachung: Bieten zirkulierende epitheliale Tumorzellen eine Entscheidungshilfe?
site of publication:
DZKF 2015, 3:15-19
The latest publications 2015
authors:
Guntinas-Lichius O, Pachmann K.
title:
Zirkulierende Tumorzellen bei Kopf-Hals-Tumoren.
site of publication:
DOI 10.1055/s-0035-1548921, Laryngo-Rhino-Otol 2015, 94:367-73
Guntinas-Lichius O, Pachmann K.
title:
Zirkulierende Tumorzellen bei Kopf-Hals-Tumoren.
site of publication:
DOI 10.1055/s-0035-1548921, Laryngo-Rhino-Otol 2015, 94:367-73
The latest publications 2015
authors:
Pachmann K.
title:
Wie beeinflußt die Therapie solider epithelialer Tumore die im Blut zirkulierenden Tumorzellen.
site of publication:
DZO 2015, 47:82-87
Pachmann K.
title:
Wie beeinflußt die Therapie solider epithelialer Tumore die im Blut zirkulierenden Tumorzellen.
site of publication:
DZO 2015, 47:82-87
The latest publications 2015
authors:
Pachmann K.
title:
Current and potential use of MAINTRAC method for cancer diagnosis and Prediction of metastasis.
site of publication:
Expert Rev Mol Diagn
Pachmann K.
title:
Current and potential use of MAINTRAC method for cancer diagnosis and Prediction of metastasis.
site of publication:
Expert Rev Mol Diagn
The latest publications 2015
authors:
Inhestern J, Oertel K, Stemmann V,Schmalenberg H, Dietz A, Rotter N, Veit J, Goerner M, Sudhoffs H, Junghans C, Wittekindt C, Pachmann K, Guntinas-Lichius O.
title:
Prognostic Role of Circulating Tumor Cells during Induction Chemotherapy Followed by Curative Surgery Combined with Postoperative Radiotherapy in Patients with Locally Advanced Oral and Oropharyngeal Squamous Cell Cancer.
site of publication:
PLoS One
Inhestern J, Oertel K, Stemmann V,Schmalenberg H, Dietz A, Rotter N, Veit J, Goerner M, Sudhoffs H, Junghans C, Wittekindt C, Pachmann K, Guntinas-Lichius O.
title:
Prognostic Role of Circulating Tumor Cells during Induction Chemotherapy Followed by Curative Surgery Combined with Postoperative Radiotherapy in Patients with Locally Advanced Oral and Oropharyngeal Squamous Cell Cancer.
site of publication:
PLoS One
The latest publications 2014
| authors: Mahal K, Schill E, Breyer S, Pachmann U, Pachmann K, Schobert R, Biersack B. |
| title: Acitivity of a Doxorubicin Menthol Conjugate against Circulating Epithelial Tumor Cells of Cancer Patients. |
| site of publication: J Pharm Sci Pharmacol 2014, 2:1-4, DOI:10.1166/jpsp.2014.1027 |
The latest publications 2014
| authors: Zimon D, Pizon M, Stein EL, Pachmann U, Pachmann K. |
| title: Differential chemosensitivity between CETCs and tumour spherodis in cancer patients with solid tumors. |
| site of publication: Europ J Cancer 2014, 50(suppl 6):62, #190 |
The latest publications 2014
| authors: Winkens T, Pachmann K, Fressmeyer M. |
| title: The influence of radioiodine therapy on the number of circulating epitzelial cells (CEC) in patients with differentiated thyroid carcioma – a pilot study. |
| site of publication: Exp Clin Endocrinol Diabetes 2014, 122: 246-253 |
The latest publications 2014
| authors: Pachmann K, Zimon D, Pizon M, Pachmann U. |
| title: Tumor spheres growing from peripherally circulating tumor cells exhibit stem cell features. |
| site of publication: Cancer Res December 15, 2013 73:PD6-1; doi:10.1158/0008-5472.SABCS13-PD6-1 |
The latest publications 2014
| authors: Pachmann K. |
| title: Tumorspheres cutured from circulating epithelial tumor cells (CETCs) as diagnostic marker in patients with solid cancers. |
| site of publication: J Clin Oncol 2014, 32:705, #11043 |
The latest publications 2014
| authors: Pachmann K. |
| title: Comparison of chemosensitivity testing of CETCs and spheroids in cancer patients with solid tumors. |
| site of publication: J Clin Oncol 2014, 32:166, #2598 |
The latest publications 2014
| authors: Pachmann K, Pizon M, Zimon D, Stein EL. |
| title: Somatic mutations of the EGFR, KRAS and BRAF genes: Heterogeneity in circulating epithelial tumor cells (CETC) as determined using the Cobas Z480 analyzer. |
| site of publication: Europ J Cancer 2013, 49(suppl.4):34(#MC13-0080) |
The latest publications 2014
| authors: Zimon D, Pizon M, Pachmann U, Pachmann, Pachmann K. |
| title: Determining the role of IGF-IR and VEGFR-2 in the development of resistance to trastuzumab in breast cancer. |
| site of publication: Oncol Res Treat 2014, 37 (suppl 5):262(#P798) |