- Mitochondria are exposed to huge oxidative stress because they use oxygen to make energy.
- They have their own DNA (mtDNA), which is much more susceptible to damage than nuclear DNA due to its proximity to the source of harmful free radicals, it’s less effective repair systems, and the lack of physical protection.
- The damage can also affect the parts inside the mitochondria which produces most of our energy currency (ATP) and even compromise the mitochondrial membrane.
- Healthy mitochondria should have sufficient antioxidants to neutralise these radicals
What is oxidative damage?
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